What is Gliclazide and what is it used for?
Gliclazide is a second-generation sulfonylurea, used for type 2 diabetes mellitus, non-insulin dependent. Its hypoglycemic action is prolonged in time and is more intense compared to glibenclamide, although the mechanism of action remains unchanged.
The active substance reaches the pancreas, and more specifically the pancreatic beta cells, stimulating the insulin secretion of immediate and late. It is prescribed when dietary measures, physical exercise and weight loss alone are not sufficient to control the level of glucose in the blood.
In fact, in type 2 diabetes, often the insulin produced by the body is not enough or is inefficient to keep glycemic levels under control. In those cases, Gliclazide tablets are useful because they serve as a stimulation for the pancreas to keep producing the hormone.
Glibenclamide is prescribed to type 2 diabetics that are not overweight and it is usually well tolerated by the body and, also, its safety as a medicinal has been validated by a huge number of clinical studies. Nonetheless, this molecule tends to lose efficiency over time, and for this reason, it will be necessary to modify the therapy after some time.
What you have to know before taking Gliclazide
Sulfonylureas are drugs that has to be taken by mouth, and they are efficient to lower glycaemia levels and to improve those related to glycated hemoglobin. On average, the use of sulfonylureas causes a 1.5 % reduction of glycated hemoglobin.
Since sulfonylureas are removed from the body after having fulfilled their purpose through the kidneys, their usage is discouraged when a deterioration of those organs is in process.
It is important to note how patients treated with sulfonylureas often experience an increase in their weight (with no side effects related to body pressure and blood lipids) caused by the growth of insulin levels in their body. For this reason is very advisable to associate the medical therapy to a constant physical exercise, as well as to a proper and healthy diet.
The side-effects of Gliclazide
Hypoglycemia could arise due to the stimulation effect of insulin secretion during the hours between meals, when the absorption of food is ended. Sulfonylureas’ hypoglycemia may last several hour and is difficult to treat. Especially in the older patient, hypoglycemia may be mistaken with sleepiness, fatigue or with the not-so-high ability to concentrate and memorize typical of this category of people. For those reasons it’s important to monitor glycaemia every time unusual symptoms does manifest.
Sulfonylureas may also increase the risks for heart attacks and other side-effects related to this drugs are nausea and vomit, even though they generally regress with time or when changing the active substance.
Suggested dosage for Gliclazide
Sulfonylureas’ effectiveness may differ from one person to another, and thus is essential to find an efficient minimum dosage, that tends to change during the course of the medical treatment.
Usually, at the beginning of the cure, 40-80mg. /day are prescribed, for an average of 2-3 pills. Maximum daily dosage is 240 mg.
The pills have to be taken via oral cavity, and have to be swallowed in their whole without chewing, with the help of some water.Preferably, Duloxetine has to be taken 30 minutes before meals.
Gliclazide will reach its maximum efficiency between two and six hours after the meals, but its action will remain effective for longer.
For more information on S.R. Gliclazide 60 mg tablets consult valpharma.com website.